CBD Oil – Paste 21% (RAW)

Product Information “CBD Oil – Paste 21% (RAW)”

One of Gallopade’s bestsellers – sold more than 2600 times in 2015

(Currently in sub-delivery, expected to be available from Wednesday, June 21, 2017.)

All products from Gallopade are based on naturally grown EU hemp plants, which contain a high proportion of CBD, the paste (oil) is extracted by Co2 extraction.

All the ingredients of the hemp plant are used in the production, so the oils contain more than 75 cannabinoids present in the plant, including CBC and CBG, as well as the rich and important terpenes.

In this way, all effective components of the hemp plant are used because we are convinced that this method is better than the extraction of CBD as an isolated active ingredient.

Contains: 10ml – Syring (21% – 2100mg CBD)

The recommended daily intake should not be exceeded. Food supplements should not be used as a substitute for a balanced and varied diet. This product must be stored out of the reach of children. The use and application of all products is at your own risk. None of the offered articles is intended to treat an existing, health condition or therapy. No medical adivce is given.

Biochemistry and botany

CBD belongs to the phytocannabinoids and occurs exclusively in plants of the genus Hemp. The genus is in the hierarchy of biological systematics below the family. Hemp (Cannabis) belongs to the family of hempfruit ( Cannabaceae ). The 11 genera of the family also include hops (humulus) and numerous species of nettle trees.

To the genus hemp belong the two kinds Cannabis sativa and Cannabis indica. In the case of cannabis ruderalis, the current state of knowledge is not an independent species. Research into the subspecies of hemp plants has not yet been completed. In addition, there are innumerable varieties of both species and hybrids between both species. The CBD content is not as often dependent on the type of hemp plant.

In the plant the CBD is formed in the same way as the THC, only in the last step the synthetic pathways differ. The share of THC and CBD is antiproportional. By increasing the THC content some popular THC-rich varieties contain almost no CBD more. CBD, on the other hand, is contained in most THC-poor “useful hemp” varieties and can thus be produced at a low price. There are many online websites which can provide Wholesale CBD to you. Here it is usually the most common cannabinoid, for example the EU variety “Fedora 17” contains 1% CBD.

Pharmacology

Contrary to THC, little is known about CBD’s mechanisms of action.

CBD binds weakly to CB1 and CB2 receptors, but acts there only as an indirect antagonist to existing agonists. Thus CBD shows only an effect, if already active substances act on the receptor. CBD also counteracts the effect of THC. This results in a lower high and less affecting the heart rate or appetite gain. THC’s medical effects can also be mitigated. In addition, it acts as an inverse agonist at the CB2 receptor, thus causing an inverse effect as agonistic, normal active substances.

The vanilloid receptor type 1 (VR1) is stimulated by CBD. This receptor plays an important role in pain relief. VR1, also referred to as capsaicin receptor, also plays a role in the sensation of taste.

CBD increases the concentration of the endocannabinoid (bodyed) anandamide by inhibiting its uptake and degradation, also in THC, it extends the duration of the activity by inhibiting the degradation via the cytochrome P450-3A (CYP3A) and 2C.

The effect of CBD on the 5-HT1A receptor causes anxiety, neuroprotective and antidepressant effects. Here it displaces agonists – depending on their concentration. In addition, CBD acts antagonistically on the G protein-coupled receptor GPR55 and acts indirectly on the μ and δ-opioid receptor.

As with the THC, there are also some synthetic cannabinoids with a similar structure or effect in CBD. The structurally similar O-1602 is one of the abnormal cannabidiolides, which does not bind to the CB1 or CB2 receptor, but acts like CBD on the GPR55. There are 7 CBD isomers, only the Δ2-CBD occurs in nature, with Δ1-CBD this has not yet been clarified.

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